Bioequivalence studies are an essential component in the development and approval of generic pharmaceutical products, ensuring that they perform similarly to their reference counterparts. These ...

Adaptive enrichment designs involve preplanned rules for modifying enrolment criteria based on accruing data in a randomized trial. We focus on designs where the overall population is partitioned into ...

This is a preview. Log in through your library . Abstract We consider conditional estimation in two-stage sample size adjustable designs and the consequent bias. More specifically, we consider a ...