This is a preview. Log in through your library . Abstract A method of interim monitoring is described for survival trials in which the proportional hazards assumption may not hold. This method extends ...

This is a preview. Log in through your library . Abstract If the maximum sample size for a group sequential t-test is calculated on the basis of a prior estimate of the variance, power at a fixed ...

The increasing interest in Bayesian group sequential design is due to its potential to reinforce efficiency in clinical trials, shorten drug development time, and enhance the accuracy of statistical ...

A genome-wide association study ascertains through genome, potential genetic associations between genetic polymorphism and observable traits or disease. 1, 2 Recent advances in DNA technology made it ...