For years, I never used the extra buttons on the side of my mouse, and mostly just viewed them as a nuisance. Too often I’d click them by accident and trigger some unwanted action, like navigating ...
In SetPoint you need to set the buttons to key presses that you don't use when you're playing. Like N, J, K, L, ;, etc. You can either do this for all applications, or figure out which .exe is running ...