Professor Kim Dale, Principal Investigator, and her team at the University’s School of Life Sciences have discovered that this mutation can disrupt how segments that later form the bones and muscle of ...

A phase 1 clinical trial of DB-020 intratympanic injections administered prior to high-dose cisplatin chemotherapy to reduce ototoxicity. This is an ASCO Meeting Abstract from the 2024 ASCO Annual ...

NOTCH1 mutations, found in 20% of CLL cases, are associated with poor outcomes in chemotherapy but not yet in treatment guidelines. A retrospective analysis showed improved PFS for NOTCH1-mutated CLL ...

Target volume delineation in locally advanced squamous cell carcinoma of the head and neck (SCCHN) using FDG-PET/CT images post-induction chemotherapy (IC). This is an ASCO Meeting Abstract from the ...

In back-to-back papers published July 28 in Science, researchers from the Broad Institute, Dana-Farber Cancer Institute, Johns Hopkins Kimmel Cancer Center, the University of Pittsburgh, and the ...

Delta-like ligand-3 (DLL3) is a single-pass, type I transmembrane protein that inhibits the Notch signaling pathway. A highly conserved intercellular signaling pathway, the Notch signaling pathway ...

Researchers have investigated the importance of the Notch pathway for the evolution of tooth morphology. Mutations in this signalling pathway can lead to defective structures in tooth enamel. Studies ...