A team of researchers has developed a method that could transform the field of protein engineering. The new approach, called AI-informed Constraints for protein Engineering (AiCE), enables rapid and ...

Protein scientists could improve reproducibility and coordination across the field by rallying around a small, shared set of ...

New method accelerates protein engineering by using structural and evolutionary constraints in inverse folding models without training specialized AI systems. (Nanowerk News) A team of Chinese ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...

Proteins are workhorses that carry out most of the biological functions in our cells. While the genes we inherit from our parents, our so-called genome, are fixed and usually remain unchanged ...

A platform to engineer enzymes responsible for the formation of amide bonds as an effort toward developing biocatalysts for green chemistry. Amide bonds — a type of chemical bond formed between a ...

Figure 1. This figure depicts the four categories of protein druggability target screening tools discussed in this section, which include structure-based methods, sequence-based methods, machine ...