Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Scientists at St. Jude Children’s Research Hospital found that subunits of the SWI/SNF chromatin remodeling complex, which is mutated in 20% of all cancers, help cells maintain a memory of ...

The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage ...

Initial efficacy and biomarker analysis of a phase 1b study targeting IL-1β and PD-1 with chemotherapy in metastatic pancreatic cancer (PanCAN-SR1). This is an ASCO Meeting Abstract from the 2022 ASCO ...

A phase IB study of the combination of selumetinib (AZD6244, ARRY-142886) and cyclosporin A (CsA) in patients with advanced solid tumors with an expansion cohort in metastatic colorectal cancer (mCRC) ...

The SWI/SNF protein complex was already known to carry out such changes, but it was unclear whether each of the three variants did so in a unique way or led to distinct macrophage behavior. To learn ...

Genetic mutations can lead to abnormal DNA transcription and, ultimately, cancer. Now, scientists at the University of Michigan have described a key nexus that several cancer-promoting genes depend on ...

In eukaryotic cells, nucleosomes—composed of histone octamers—address the topological challenge of DNA packaging by condensing the DNA within the nucleus., crucial for genetic information storage and ...

In a recent article published in Nature Genetics, researchers showed that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes represent a potential class of ...

Scientists have determined how the SWI/SNF chromatin remodeling complex helps cancer cells 'remember' how to be cancerous after division. When a cell divides, it retains information about how to grow ...