Two-step genome editing enables creation of full-length humanized mouse models

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

The fastest human spaceflight mission in history crawls closer to liftoff

The Artemis II mission will set several notable human spaceflight records. Astronauts Reid Wiseman, Victor Glover, Christina ...

How’d they do that? ‘Sinners’ cinematographer explains how they burned the house down in one take

Sinners was lovingly captured on 65 millimeter film by Coogler and cinematographer Autumn Durald Arkapaw ( Black Panther: ...

'I consider it a millennial shooter': The FPS dev making hit shooters by leaning into '2007-core'

Echo Point Nova's Matt Larrabee talks movement shooters, making niche games, and '2007-core' game design.
eLife

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.