UT Southwestern Medical Center researchers have discovered that increasing the levels of a protein called BACH2 makes ...
Scientists have demonstrated a dependable method to generate large numbers of helper T cells from stem cells, removing a long-standing obstacle that has limited immune-based cancer treatments. The ...
A small number of cancer cells with the ability to change their identities and behaviors appear to be a key driver of cancer ...
Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...
According to the American Cancer Society, colorectal cancer is the second leading cause of cancer death. Enrichment of regulatory T cells (T-regs) in solid cancers is generally associated with poor ...
High numbers of regulatory T cells (red) — seen here interacting with antigen-presenting cells (blue) — are usually associated with poorer outcomes in cancer. A new MSK study, however, found that a ...
Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by ...
Scientists analyzing human and mouse pancreatic lymph nodes (PLNs) and spleens have identified a distinct subset of CD4 memory helper T cells associated with type 1 diabetes (T1D). Reported by ...
CAR T therapy improves survival in B-cell malignancies but presents toxicities like CRS, ICANS, ICAHT, and IEC-HS, requiring careful management. ICAHT is classified into early and late phases, with ...
Killer immune cells destroy cancer cells and cells infected by virus. These CD8 + T cells are activated after detection of viral infection or growth of “non-self” tumor cells. However, in chronic ...
Regulatory T cells (Tregs) are a small, unique subset of suppressive T cells that play a pivotal role in regulating the immune system by maintaining tolerance to self-antigens and preventing ...